Crystal engineering of zwitterionic drug to neutral co-crystals
نویسندگان
چکیده
منابع مشابه
Zwitterionic co - crystals
Zwitterionic co-crystals family could be basis for very different structural and theoretical examinations as their ability to alter solubility and deliver a wide solubility spectrum is receiving more attention. Many zwitterionic co-crystals crystal structures exhibited carboxylate-hydroxyl supramolecular heterosynthons preference. In addition to examples of zwitterionic co-crystals in the Cambr...
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We review the key topics of one of the areas with the biggest impact of the last years in the chemical and pharmaceutical industry that is Crystal Engineering. The relevance of polymorphs and co-crystals from different points of view is been highlighted and broadly illustrated by means of several recent examples of studies carried out in this field. In addition, the most suitable instrumental t...
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A new 2:1 co-crystal of piroxicam and gentisic acid [systematic name: 4-hy-droxy-1,1-dioxo-N-(pyridin-2-yl)-2H-1λ6,2-benzo-thia-zine-3-carboxamide-2-(4-oxido-1,1-dioxo-2H-1λ6,2-benzo-thia-zine-3-amido)-pyridin-1-ium-2,5-di-hydroxy-benzoic acid, 2C15H13N3O4S·C7H6O4] has been synthesized using a microfluidic platform and initially identified using Raman spectroscopy. In the co-crystal, one piroxi...
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A number of hydrogen-bonded co-crystals, consisting of a cinnamic acid derivative and a pyridyl co-crystallizer, have been synthesized and their properties investigated by X-ray diffraction. Samples were prepared by recrystallization or solvent drop grinding of trans-cinnamic acid (1), 4-methylcinnamic acid (2), 4-methoxy cinnamic acid (3) or 3,4-methoxy cinnamic acid (4), with 4,4-dipyridyl (A...
متن کاملCrystal engineering of pharmaceutical co-crystals from polymorphic active pharmaceutical ingredients.
The carboxylic acid-primary amide supramolecular heterosynthon is exploited for the generation of pharmaceutical co-crystals that contain two active pharmaceutical ingredients that are polymorphic in their pure forms.
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations and Advances
سال: 2017
ISSN: 2053-2733
DOI: 10.1107/s2053273317085333